Microsoft Research and Paige, now part of Tempus, published a study in Nature Medicine describing PRISM2, a pathology foundation model trained on paired tissue images and text derived from real pathology reports. Training used millions of question-and-answer examples linking visual findings to diagnostic language, and the model accepts images alone or images with text prompts. In benchmark testing, PRISM2 matched or exceeded specialized single-task cancer-detection systems on prostate cancer, breast cancer and breast lymph node metastasis detection without training a separate model per task. Full model weights are publicly available for research use on Hugging Face under the paige-ai/Prism2 and paige-ai/Prism2-survival repositories.

• news.microsoft.com2026-08-04