Researchers used AI to analyze 101,243 PET-CT scans of adult patients. Detectable brown fat linked to lower rates of heart and metabolic diseases. It also linked to fewer psychiatric conditions. Higher brown fat activity in the axillary region tied to better metabolic results. Losartan increased brown fat activity in lab and mouse tests. Its effect on human brown fat remains untested. The study could not prove brown fat prevents disease. Findings appeared in Nature.
What changed
Manual BAT quantification from whole-body scans was labor-intensive and limited to small studies.
What it unlocks
AI-enabled mapping of brown fat links to cardiometabolic and psychiatric health outcomes.
- 101,243 PET-CT scans analyzed
- 58% lower odds of type 2 diabetes
- 47% lower odds of chronic ischaemic heart disease
What you need to act on it
- retrospective clinical PET-CT data
- AI image-analysis system
Sources