Researchers at the University of Southampton and University Hospital Southampton released CenSegNet, free open-source software that uses AI to map abnormalities in cell structures called centrosomes across whole tumour samples. Applied to breast cancer tissue, it separated two distinct types of defect that had been treated as one, and linked enlarged centrosomes to more aggressive disease. The tool is not ready for routine clinical use.
What changed
Centrosome defects in patient tissue could not be mapped cell by cell across whole tumours.
What it unlocks
Mapping centrosome abnormalities at single-cell level across entire tumour samples using freely available software.
- 127 breast cancer patients
- 330,000+ centrosomes analysed
- 911 tumour specimens
What you need to act on it
- research setting with tumour tissue imaging
- not approved for routine clinical use
Sources